Blog | Resolve

Best B2B Payment Platforms for Pharmaceutical Manufacturers

Written by Resolve Team | Feb 12, 2026 8:56:39 AM

The pharmaceutical industry faces unique payment challenges that demand specialized solutions. With global medicines spending projected to reach $1.9 trillion by 2027, and with material revenue leakage tied to chargebacks and rebates across the sector, selecting the right B2B payment platform is critical for protecting margins and ensuring audit-ready operations. Pharmaceutical manufacturers require platforms that handle high-value transactions (often six figures), support extended payment terms that can strain cash flow, and meet strong security and control requirements (PCI DSS; and where applicable HIPAA), plus enterprise audit controls (e.g., SOC 2/ISO 27001). For manufacturers looking to streamline their financial operations while offering flexible payment terms, Resolve's B2B Net Terms platform provides a comprehensive solution that addresses these specific industry challenges.

Key Takeaways

  • Pharmaceutical manufacturers need B2B payment platforms that handle high-value transactions, extended payment terms, and strict regulatory compliance requirements (FDA, HIPAA, PCI DSS)
  • Non-recourse financing solutions eliminate credit risk while providing instant approvals and rapid funding, addressing the pharmaceutical industry's extended payment cycles
  • AI-powered payment platforms can deliver instant credit decisions (where financing/net terms are offered) and automated cash application with high match rates, reducing manual reconciliation for complex invoices
  • Industry-specific platforms offer specialized features like pharma distribution/ERP integrations, chargeback/deduction workflow support, and security/compliance documentation controls
  • Global pharmaceutical manufacturers benefit from payment orchestration platforms that connect to hundreds of payment service providers through single integrations
  • Comprehensive AR automation with seamless ERP integration enables pharmaceutical companies to manage the entire credit-to-cash lifecycle efficiently

1. Resolve Pay - AI-Powered Non-Recourse B2B BNPL

Resolve Pay offers pharmaceutical manufacturers a unique advantage: 100% non-recourse financing that eliminates credit risk while providing instant approvals and 24-hour funding. Unlike traditional factoring or payment processors, Resolve takes on the credit assessment, credit decision, and majority risk of late payments or defaults, allowing pharma companies to offer net terms without jeopardizing their cash flow.

Best For

Pharmaceutical manufacturers need to offer net terms without credit risk, with instant approvals supporting high-value B2B transactions.

Key Features

  • 100% non-recourse financing eliminates merchant credit risk completely
  • AI-powered instant credit decisions with up to 100% invoice advance
  • Enterprise ERP integration supporting NetSuite, QuickBooks, and SAP
  • Automated AR workflow with payment reminders and collections management
  • 24-hour funding cycles that address extended payment term challenges
  • Seamless integration with Accounts Receivable with AI-Powered Automation

Pharmaceutical Relevance

Resolve's platform is particularly valuable for pharmaceutical manufacturers who need to extend credit to healthcare providers, hospitals, and distributors while maintaining healthy cash flow. The platform's ability to advance up to 100% of invoice value within 24 hours directly addresses the industry's extended payment cycle challenges. With a significant portion of pharma B2B sales made on credit, having a solution that manages the entire credit-to-cash lifecycle is essential.

The non-recourse nature of Resolve's financing means pharmaceutical manufacturers can confidently offer competitive payment terms to grow their customer base without worrying about default risk. This is particularly valuable in the pharmaceutical sector where building long-term relationships with healthcare providers and distributors often requires flexible credit terms.

Customer Validation

"Resolve has positively impacted our cash flow. Their advance on each invoice we submit has translated into quicker receivables, directly contributing to healthier cash flow management," shared Luke Elliot, Co-Founder of RentAll Construction, a Resolve client.

Resolve's AI-powered underwriting provides instant credit approvals compared to the multi-day processes typical of traditional methods, enabling pharmaceutical manufacturers to respond quickly to customer orders. The platform's automated collections management reduces the administrative burden on AR teams while maintaining professional customer relationships.

2. Billtrust

Billtrust processes $1 trillion annually and has proven success specifically in the pharmaceutical sector. Their platform combines digital lockbox technology with AI-powered cash application that achieves 86.3% match rates, significantly reducing manual reconciliation for complex pharmaceutical invoices.

Best For

Large pharmaceutical manufacturers and distributors with complex AR needs and high transaction volumes.

Key Features

  • Digital Lockbox for automated virtual card processing
  • AI-powered cash application with 86.3% match rates
  • Level 2/3 card data capture for reduced interchange fees
  • Pharmaceutical distributor case study showing significant annual savings

Pharmaceutical Relevance

Billtrust's pharmaceutical distributor case study demonstrates real-world value: a 2.9% to 2.1% drop in processing fees and $110,000 in annual savings. Given that pharmaceutical transactions can reach substantial values, their specialized handling of high-value pharmaceutical transactions provides significant operational efficiency.

Industry Validation

A pharmaceutical distributor recaptured valuable employee time processing one-off credit card payments with Billtrust, achieving $110,000 in annual savings and significant processing fee reduction.

3. Curbstone

Curbstone is built specifically for pharmaceutical distribution, featuring native integration with Iptor Pharma ERP and addressing the industry's substantial chargeback challenges. Their PCI-validated Level 1 Service Provider status with remote tokenization ensures compliance with strict pharmaceutical security requirements.

Best For

Pharmaceutical manufacturers using Iptor Pharma ERP or those experiencing significant chargeback issues.

Key Features

  • Native integration with Iptor Pharma ERP
  • Chargeback protection addressing industry-specific challenges
  • Real-time IBM i integration for pharmaceutical distribution
  • PCI-validated Level 1 Service Provider with remote tokenization

Pharmaceutical Relevance

The pharmaceutical industry faces significant annual losses to chargebacks and rebate abuse, making Curbstone's specialized protection particularly valuable. Their out-of-the-box Iptor Pharma ERP integration eliminates the need for custom development, which is especially beneficial for manufacturers already using this industry-specific ERP system.

4. DEUNA

DEUNA provides payment orchestration specifically designed for pharmaceutical companies scaling globally. Their platform connects to 400+ global payment and fraud providers through a single integration, offering dynamic payment routing for higher approval rates and region-specific fraud mitigation for pharmaceutical transactions.

Best For

Pharmaceutical manufacturers with global operations requiring multi-region payment processing capabilities.

Key Features

  • One integration connects to 400+ global payment and fraud providers
  • Dynamic payment routing for higher approval rates
  • Region-specific fraud mitigation for pharmaceutical transactions
  • Unified reconciliation dashboard for complex payment flows

Pharmaceutical Relevance

With the pharmaceutical market experiencing substantial growth, DEUNA's platform is built to support this scale. Their solution supports both B2B (corporate cards) and B2C (digital wallets) pharmaceutical sales, making them ideal for manufacturers serving diverse customer segments across multiple regions.

5. Xflow

Xflow specializes in cross-border B2B payments with transparent FX rates and no hidden markups, offering significant cost savings compared to traditional banks. Their 45-day FX rate lock and automated FIRC/FIRA compliance documentation are particularly valuable for pharmaceutical manufacturers with global supply chains.

Best For

Pharmaceutical manufacturers with significant international transactions requiring FX optimization and compliance automation.

Key Features

  • Multi-currency virtual accounts with transparent FX rates
  • 45-day FX rate lock for international transactions
  • Automated FIRC/FIRA compliance documentation
  • Substantial savings on FX costs with no hidden markups

Pharmaceutical Relevance

Pharmaceutical manufacturers frequently engage in cross-border transactions for raw materials, distribution, and sales. Xflow's automated compliance documentation for international pharmaceutical transactions (FIRC, AML, KYC) reduces administrative burden while their transparent FX rates protect margins on international deals.

Industry Validation

Businesses process payments faster with digital platforms like Xflow, achieving significant savings on FX costs compared to traditional banking solutions.

6. Versapay

Versapay processes $257 billion annually with strong customer satisfaction, offering a PayFac model that ensures faster onboarding for complex pharmaceutical use cases. Their Level 2/3 data capture reduces interchange fees by up to 40%, providing significant cost savings for high-value pharmaceutical transactions.

Best For

Pharmaceutical companies seeking comprehensive AR automation with healthcare experience.

Key Features

  • PayFac model ensures fast onboarding for complex use cases
  • Level 2/3 data capture reduces interchange fees up to 40%
  • Native ERP integrations (NetSuite, Sage, Microsoft Dynamics)
  • Processes $257B annually with high customer satisfaction

Pharmaceutical Relevance

Versapay's healthcare experience is demonstrated through successful pharmaceutical implementations. Their PayFac status enables faster onboarding than traditional payment processors, which is valuable for pharmaceutical companies needing to implement solutions quickly.

7. Stripe

Stripe offers extensive developer tools and API documentation among payment platforms, supporting 135+ currencies for global pharmaceutical supply chains. Their robust fraud prevention and deep integration capabilities make them suitable for custom pharmaceutical workflows.

Best For

Pharmaceutical companies with in-house development teams needing robust global payment processing with extensive customization.

Key Features

  • Extensive developer tools and API documentation
  • Global payment acceptance in 135+ currencies
  • Deep integration capabilities with customization options
  • Robust fraud prevention with global reach

Pharmaceutical Relevance

Pharmaceutical manufacturers often require custom integrations with internal systems, regulatory databases, and specialized workflows. Stripe's extensive APIs enable these customizations while their global reach supports international pharmaceutical supply chains and sales operations.

8. PayPal/Braintree

PayPal/Braintree leverages strong buyer trust and brand recognition in payment processing, making it ideal for pharmaceutical buyers who prefer established, trusted payment methods for high-value purchases. Braintree offers white-glove B2B service with deep reconciliation capabilities.

Best For

Pharmaceutical companies prioritizing buyer trust and brand recognition for high-value purchases.

Key Features

  • Buyer trust through established brand recognition
  • International payment support
  • Credit management and fraud prevention
  • Braintree white-glove B2B service with deep reconciliation

Pharmaceutical Relevance

Pharmaceutical buyers often prefer established, trusted payment brands for high-value purchases due to security concerns and compliance requirements. PayPal's brand recognition provides confidence, while Braintree's B2B-focused service offers the specialized features needed for pharmaceutical transactions.

9. Mastercard B2B Solutions

Mastercard B2B Solutions provides enterprise-grade virtual card platforms for pharmaceutical procurement, with a global commercial card network optimized for high-value pharma transactions. Their partnership with TreviPay enables net-terms purchasing for pharmaceutical buyers.

Best For

Large pharmaceutical manufacturers needing virtual card solutions and global commercial card acceptance.

Key Features

  • Virtual card platform for pharmaceutical procurement
  • Commercial card payment acceptance network
  • Partnership with TreviPay for net terms B2B payments
  • Enhanced B2B payments across EMEA through 4thWave partnership

Pharmaceutical Relevance

Large pharmaceutical manufacturers often use virtual cards for procurement and supplier payments. Mastercard's enterprise virtual card platform supports these high-value transactions while their TreviPay integration enables net-terms purchasing, addressing the industry's need for flexible payment terms.

Recent Development

Mastercard's partnership with TreviPay for B2B payment expansion (January 2024) enhances their net-terms capabilities for pharmaceutical buyers.

10. Payoneer

Payoneer offers multi-currency accounts and mass payout capabilities ideal for small-to-medium pharmaceutical manufacturers with global supplier networks. Their Zoho Books integration (April 2023) and strong marketplace integration support pharmaceutical e-commerce platforms.

Best For

Small-to-medium pharmaceutical manufacturers with global supplier networks needing multi-currency capabilities.

Key Features

  • Multi-currency accounts for pharmaceutical suppliers
  • Integration with global marketplaces and platforms
  • Mass payout capabilities for pharmaceutical distributors
  • Zoho Books integration for pharmaceutical accounting

Pharmaceutical Relevance

Small-to-medium pharmaceutical manufacturers often work with global supplier networks and require multi-currency capabilities to manage international payments efficiently. Payoneer's marketplace integration supports pharmaceutical e-commerce platforms, making it suitable for manufacturers selling through digital channels.

Recent Development

Payoneer's Zoho Books integration announced in April 2023 enhances accounting capabilities for pharmaceutical SMEs.

Choosing the Right B2B Payment Platform for Your Pharmaceutical Business

Selecting the right B2B payment platform for pharmaceutical manufacturing requires careful evaluation of your specific operational needs, transaction volumes, and growth trajectory. The pharmaceutical industry's unique challenges—including high-value transactions, extended payment terms, strict regulatory compliance, and complex global supply chains—demand payment solutions purpose-built for these requirements.

For pharmaceutical manufacturers seeking to eliminate credit risk while maintaining healthy cash flow, Resolve Pay's non-recourse financing model offers a compelling solution. The platform's ability to advance up to 100% of invoice value within 24 hours while assuming the credit risk enables manufacturers to offer competitive net terms without jeopardizing their financial position. This becomes particularly valuable when working with healthcare providers, hospitals, and distributors who expect flexible payment options.

The instant credit approval capabilities powered by AI underwriting accelerate the order-to-cash cycle, enabling pharmaceutical manufacturers to respond quickly to customer orders without the multi-day delays typical of traditional credit evaluation processes. Combined with seamless ERP integration supporting NetSuite, QuickBooks, and SAP, Resolve Pay provides pharmaceutical manufacturers with a comprehensive platform that addresses both immediate cash flow needs and long-term customer relationship management.

As the pharmaceutical market continues its substantial growth trajectory, having a B2B payment platform that scales with your business while maintaining security, compliance, and operational efficiency becomes increasingly critical. Whether you're a large enterprise manufacturer processing high transaction volumes or a growing pharmaceutical company looking to expand your customer base through flexible payment terms, the right payment platform serves as strategic infrastructure that supports sustainable growth.

Frequently Asked Questions

How can B2B payment platforms address the long payment cycles common in the pharmaceutical industry?

Platforms like Resolve Pay address the pharmaceutical industry's extended payment terms by advancing up to 100% of invoice value within 24 hours while customers maintain their standard payment terms. This non-recourse financing model eliminates the cash flow strain without requiring customers to change their payment behavior. The manufacturer receives immediate funding while the payment platform manages credit risk and collections.

What role does AI play in modern B2B payment solutions for pharmaceutical manufacturers?

AI powers instant credit decisions, automated cash application with high match rates, and intelligent payment routing for higher approval rates. For pharmaceutical manufacturers, AI reduces manual processing of complex invoices and accelerates credit decisions from days to seconds. This automation enables faster order fulfillment and improved customer experience while reducing administrative overhead on AR teams.

How can implementing a B2B payment platform improve cash flow for pharma manufacturers?

B2B payment platforms improve cash flow through invoice financing, automated AR workflows that reduce DSO (Days Sales Outstanding), and interchange optimization that reduces processing fees. Platforms offering non-recourse financing provide immediate access to capital while eliminating credit risk. Additionally, automated collections management and payment reminders reduce the time and resources required to manage accounts receivable.

What security and compliance features should pharmaceutical manufacturers look for in a payment platform?

Pharmaceutical manufacturers should prioritize platforms offering PCI DSS compliance, HIPAA compliance capabilities, FDA-aware security protocols, and robust fraud prevention systems. Look for features like tokenization, encrypted data transmission, secure API integrations, and comprehensive audit trails. Platforms with industry-specific certifications demonstrate their understanding of pharmaceutical regulatory requirements and commitment to maintaining appropriate security standards.

Can B2B payment platforms integrate with existing pharmaceutical ERP systems?

Yes, leading B2B payment platforms offer native integrations with major ERP systems commonly used in pharmaceutical manufacturing, including NetSuite, SAP, QuickBooks, Microsoft Dynamics, and industry-specific systems like Iptor Pharma. These integrations enable automated invoice synchronization, real-time payment updates, and seamless financial reconciliation. When evaluating platforms, verify that they support your specific ERP system and understand the depth of integration available—some platforms offer basic data export while others provide comprehensive two-way synchronization with automated workflows.

This post is to be used for informational purposes only and does not constitute formal legal, business, or tax advice. Each person should consult his or her own attorney, business advisor, or tax advisor with respect to matters referenced in this post. Resolve assumes no liability for actions taken in reliance upon the information contained herein.